Capabilities

In blister printing

Innovative Technology. Transformative Capabilities.

Tough challenges require robust solutions. Aprecia has multiple technologies, decades of expertise, and a range of specialty services. We can redefine medicine … together.

Your Solution Has Never Been So Suite

Whether you need assistance in navigating early-stage development or managing an existing product’s lifecycle, Aprecia’s expert team and unique suite of advanced technologies in precision formulation, oral drug delivery forms, and 3DP production can meet your needs.

Precision Formulation

Aprecia’s 3DP development expertise can help you transcend traditional formulation limitations. From pre-formulation studies to formulation development, analytical development, process development, and scale-up, we can creatively solve your challenges with patented 3DP technology.

pill under a microscope

Drug Delivery Forms

Our pioneering 3DP manufacturing process offers flexible oral dosage forms with tailored functionalities and a range of API compatibility.

Flexible Oral Administration

Traditional Tablets
Sublingual/Buccal Tablets
Orodispersible Tablets

Embedded Functionality

Taste Masking
Modified Release
Enhanced Bioavailability

Broad API Compatibility

High Dose
Ultra-Low Dose
Fixed-Dose Combos
High-Potent Capabilities

3DP PRODUCTION TECHNOLOGY PLATFORMS

Aprecia offers distinct, patent-protected 3DP production platforms—our Open Bed 3DP-Tablet Forming Platform and our In- Blister 3DP-Tablet Production Platform.

For Feasibility and Early Formulation

Our 3DP production platforms increase R&D throughput by enabling fast and efficient feasibility assessments and rapid prototyping.

For Clinical Trial and Low Volume Market Supply

Each platform can produce clinical supplies suitable for Phase I-III trials.

For Commercial-Scale Production

Our Open Bed Production Platform is commercial ready, with breakthrough binder jetting innovations that can deliver capacity at scale.

Open Bed 3DP-Tablet Forming Platform

Aprecia’s Open Bed 3DP-Tablet Forming Platform enables 3DP-tablet printing without molds or dyes, so tooling is unnecessary when adjusting geometries or spatial compositions. The system can produce orodispersible dosage forms in excess of 1000 mg of active ingredients.

  • For development, uses bed-to-bed transfer of powder for rapid prototyping with expensive and/or scarce API during feasibility and early formulation.
  • For commercial-scale production, uses a cam-driven oval “racetrack” consisting of linked moving build trays; also features continuous powder feeding and spreading, stationary high resolution printheads, unprinted powder capture and recirculation, and a humidity-controlled drying oven.
Z-Free Product

IN BLISTER 3DP-TABLET PRODUCTION SYSTEM

The Aprecia In Blister 3DP-Tablet Production System enables 3DP-tablet printing in the primary packaging and layer-by-layer precision control.

  • Combine multiple APIs
  • Integrated PAT (Process Analytical Technology)
  • In-line inspection
  • Printing of unique logos on tablet surface
  • Traceability at the card and cavity level
  • High-potent capabilities
In Blister 3D Tablet Production System Screen

Aprecia Z-FORM FLEX

scientists-working-together

Comprehensive CMC Support

At Aprecia, we provide unparalleled CMC support. Our team of seasoned experts offers in-depth guidance on quality and regulatory compliance from initial development through commercialization, ensuring your products meet the highest industry standards worldwide.

Our CMC services encompass a range of activities, including:

  • Raw Materials: We assist in the selection and testing of raw materials to ensure they meet the required specifications and are suitable for your product’s formulation.
  • Analytical Methods: Our team specializes in the development and validation of analytical methods, crucial for accurately monitoring product attributes.
  • Stability Testing: We conduct comprehensive stability testing to evaluate how your product withstands various environmental conditions over time, ensuring its safety and efficacy until the end of its shelf life.
  • Physicochemical Properties: Determining the physicochemical properties of your product is essential. Our experts carry out detailed analyses to understand these properties, which inform formulation and manufacturing decisions.
  • Manufacturing: We define best practices and establish scalable manufacturing methods to facilitate large-scale production while maintaining product quality and integrity.
  • Quality Control: Implementing stringent quality control measures is paramount. We develop and oversee protocols to ensure that each batch of your product conforms to predefined standards, minimizing risks and maintaining consistency.

Connect with the 3DP Technology Experts

Contact Us