Innovative Technology. Transformative Capabilities.
Tough challenges require robust solutions. Aprecia has multiple technologies, decades of expertise, and a range of specialty services. We can redefine medicine … together.
Your Solution Has Never Been So Suite
Whether you need assistance in navigating early-stage development or managing an existing product’s lifecycle, Aprecia’s expert team and unique suite of advanced technologies in precision formulation, oral drug delivery forms, and 3DP production can meet your needs.
Precision Formulation
Aprecia’s 3DP development expertise can help you transcend traditional formulation limitations. From pre-formulation studies to formulation development, analytical development, process development, and scale-up, we can creatively solve your challenges with patented 3DP technology.
Drug Delivery Forms
Our pioneering 3DP manufacturing process offers flexible oral dosage forms with tailored functionalities and a range of API compatibility.
Flexible Oral Administration
Traditional Tablets
Sublingual/Buccal Tablets
Orodispersible Tablets
Embedded Functionality
Taste Masking
Modified Release
Enhanced Bioavailability
Broad API Compatibility
High Dose
Ultra-Low Dose
Fixed-Dose Combos
High-Potent Capabilities
3DP PRODUCTION TECHNOLOGY PLATFORMS
Aprecia offers distinct, patent-protected 3DP production platforms—our Open Bed 3DP-Tablet Forming Platform and our In Blister 3DP-Tablet Production Platform.
For Feasibility and Early Formulation
Our 3DP production platforms increase R&D throughput by enabling fast and efficient feasibility assessments and rapid prototyping.
For Clinical Trial and Low Volume Market Supply
Each platform can produce clinical supplies suitable for Phase I-III trials.
For Commercial-Scale Production
Our Open Bed Production Platform is commercial ready, with breakthrough binder jetting innovations that can deliver capacity at scale.
Open Bed 3DP-Tablet Forming Platform
Aprecia’s Open Bed 3DP-Tablet Forming Platform enables 3DP-tablet printing without molds or dyes, so tooling is unnecessary when adjusting geometries or spatial compositions. The system can produce orodispersible dosage forms in excess of 1000 mg of active ingredients.
- For development, uses bed-to-bed transfer of powder for rapid prototyping with expensive and/or scarce API during feasibility and early formulation.
- For commercial-scale production, uses a cam-driven oval “racetrack” consisting of linked moving build trays; also features continuous powder feeding and spreading, stationary high resolution printheads, unprinted powder capture and recirculation, and a humidity-controlled drying oven.
IN BLISTER 3DP-TABLET PRODUCTION SYSTEM
The Aprecia In Blister 3DP-Tablet Production System enables 3DP-tablet printing in the primary packaging and layer-by-layer precision control.
- Combine multiple APIs
- Integrated PAT (Process Analytical Technology)
- In-line inspection
- Printing of unique logos on tablet surface
- Traceability at the card and cavity level
- High-potent capabilities
In Blister 3DP-Tablet Production System
Comprehensive CMC Support
At Aprecia, we provide unparalleled CMC support. Our team of seasoned experts offers in-depth guidance on quality and regulatory compliance from initial development through commercialization, ensuring your products meet the highest industry standards worldwide.
Our CMC services encompass a range of activities, including:
- Raw Materials We assist in the selection and testing of raw materials to ensure they meet the required specifications and are suitable for your product’s formulation.
- Analytical Methods Our team specializes in the development and validation of analytical methods, crucial for accurately monitoring product attributes.
- Stability Testing We conduct comprehensive stability testing to evaluate how your product withstands various environmental conditions over time, ensuring its safety and efficacy until the end of its shelf life.
- Physicochemical Properties Determining the physicochemical properties of your product is essential. Our experts carry out detailed analyses to understand these properties, which inform formulation and manufacturing decisions.
- Manufacturing We define best practices and establish scalable manufacturing methods to facilitate large-scale production while maintaining product quality and integrity.
- Quality Control Implementing stringent quality control measures is paramount. We develop and oversee protocols to ensure that each batch of your product conforms to predefined standards, minimizing risks and maintaining consistency.